What every major chain does on each US holiday — quick answers, plus links to the 24-hour fallback options.
December 25
Christmas Day is the single biggest closure day for chain pharmacies in the United States. Most stores close entirely; a small subset of 24-hour CVS and Walgreens locations stay open with limited pharmacy service.
All chains →the fourth Thursday of November
Thanksgiving is the second-largest closure day. Most pharmacy counters are closed; some 24-hour drugstores keep front-store hours but the pharmacy itself is dark.
All chains →January 1
New Year's Day is a partial closure day. Most chains operate on Sunday or shortened holiday hours; pharmacy counters typically open later and close earlier than the front store.
All chains →a moveable date in late March or April
Easter Sunday sees most pharmacies open with Sunday or shortened holiday hours. Costco is the major exception — every warehouse and pharmacy is closed.
All chains →the last Monday of May
Memorial Day operates on holiday hours at most chains. The major retail pharmacies stay open with regular or slightly reduced schedules; Costco closes entirely.
All chains →the first Monday of September
Labor Day is treated similarly to Memorial Day — most chains keep regular Monday hours, Costco closes warehouses and pharmacies.
All chains →July 4
Independence Day is a normal operating day at most national pharmacy chains, with a few stores opting for slightly reduced hours. Costco is closed; everyone else is open.
All chains →